Commercial Breeding for Laboratories

Clive Efford Excerpts

Monday 16th January 2023 Westminster Hall

[Elliot Colburn]

My hon. Friend is absolutely right. The evidence demonstrates that animal testing has very little benefit. I think we are in the single figures when we look at the percentage of tests that have gone from being successful in animals to successful in humans. It is a waste of money, and we should therefore increasingly be looking to consign animal testing to the dustbin of history. To give a further example, a 2019 study found that it could not recommend any animal model that could reliably predict the efficacy of potential treatments for Alzheimer’s, which is one of the largest health challenges facing this country.

Finally, I want to talk about what the petition is calling for—a NAMs committee—and expand a little on what NAMs, or non-animal methods, are. Because of technological advancements, NAMs have the power not only to replace animal testing but to improve the robustness of the testing that we do, provide more accurate results and be more cost-effective. They are directly relevant to human patients, so they are much more likely to provide the scientific and medical breakthroughs that we are looking for than animal testing. There is growing evidence that NAMs are able to predict potential harms to patients from new drugs that were not identified by animal tests. For example, a recent study found that Emulate’s liver-on-chips were able to correctly identify 87% of drugs that caused drug-induced liver injury to patients despite passing through animal testing. University of Oxford researchers have developed an animal-free model of stroke by using organ-on-a-chip technology. They were able to replicate the blood-brain barrier and mimic a stroke, which creates new possibilities for testing stroke drugs in human cells.

Without regulatory change, the Government could create a NAMs committee to ensure that the UK legal framework is enforced. An independent NAMs specialist committee could review applications for project licences prior to approval so that a licence is granted only if there truly is no replacement method. If the committee felt that that was not the case, it could refer the application back to the applicant, and those assessing it, with advice on where to find appropriate NAMs to meet the research or testing need. That would help to ensure that, as the 1986 Act stipulates, animal testing licences are granted only if there are no appropriate replacements, and it would promote the wider use, research and development of NAMs. A NAMs committee could be constructed in the same way as the existing, animals in science committee: as an advisory, non-departmental public body that is sponsored by the Home Office. Members would be independent NAMs experts who represent a wide range of expertise.

Those proposals are not something that I or the petition creators have picked out of thin air; they are already being implemented across the world. The most recent development came just in December last year, when US President Biden signed the FDA Modernisation Act 2.0, which will make it easier for researchers to choose non-animal testing methods. I strongly believe that if the US can do it, we can do it too—and make a success of it.

I reiterate, as my hon. Friend the Member for Rother Valley (Alexander Stafford) mentioned, our fantastic record of implementing animal welfare reforms, including the recent Animal Welfare (Sentience) Act 2022, the Ivory Act 2018, the Animal Welfare (Sentencing) Act 2021, which increased the maximum penalties for animal cruelty, and so much more. However, this issue is a glaring omission. I hope that the Minister can update the House on what steps her Department is taking to address problems surrounding commercial breeding, what investigations there are into the MBR Acres site, and what consideration she has given to establishing a NAMs committee, so that the UK can finally adopt the three Rs, adhere to the letter of the 1986 Act and move away from animal exploitation in favour of innovation.

[Clive Efford (in the Chair)]

I remind Members that they should bob—be on their feet—if they wish to be called. I will not impose a fixed time limit at the moment, but roughly six minutes per speech should see us comfortably home and allow time for the Front-Bench spokespeople and Elliot Colburn to wind up.

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[Dr Rupa Huq (Ealing Central and Acton) (Ind)]

It is a pleasure to serve under your chairmanship, Mr Efford.

I am here today because three separate constituents have come to my Friday surgery and opened my eyes to how the existing framework in this country is ethically, practically, morally and scientifically bankrupt. I pay tribute to the valiant protesters at Camp Beagle who, for 18 months, have been outside the gates of Marshall Bio Resources in Cambridgeshire—it is happening not too far from here.

I was sent some secretly obtained footage of just a couple of minutes, not highlights culled from several hours, and it was concerning and upsetting to see the barbaric conditions that the beagles are kept in, as my hon. Friend the Member for Canterbury (Rosie Duffield) said. Beagles are good-natured animals who will not bite back, as my hon. Friend the Member for Bristol East (Kerry McCarthy) pointed out. They are bred in factory conditions, with no space to run around. They have never experienced sunshine, wind, rain or any such things—no natural light. I think there were some pictures of them eating faeces, so God knows what diet they are given.

In those beagles’ lifetime, after 16 weeks—they are only babies, puppies—they go to laboratories and who knows what happens. They are injected with bleach, fertiliser and all such things, even at that young age. They are sentient beings, just as we are, and that should not continue. MBR Acres sounds quite nice, as if the beagles are running around, gambolling in the fields, but that is far from the case, and every time what happens to them is put to MBR Acres, it says it is fully compliant with the law and a fully licensed establishment. That law, however, as my hon. Friend the Member for Canterbury pointed out, is the Animals (Scientific Procedures) Act 1986—but 1986 was a different world. Even I was at school at then. How many Prime Ministers have we had since then—okay, we have had three this year alone—and there was not even the internet.

People ask: “What is the alternative?” We heard about NAMs, the non-animal routes we should be going down, as was pointed out by my hon. Friend the Member for Kingston upon Hull West and Hessle (Emma Hardy). There is a better way of doing things: cutting-edge technologies, modelling three-dimension cell cultures, organs on chips, artificial intelligence. That all harnesses scientific progress. Why are we still stuck in 1986, when “The Chicken Song” by Spitting Image—“Hold a chicken in the air”—was No. 1? It was a completely different world.

The Cruelty Free International pressure group sets everything out in a detailed plan. We could have a regulator, or even a committee to mirror the Animals in Science Committee, a NAMs committee that could monitor such things. ASPA, the 1986 Act, sets out just bare-minimum guidelines, not even best practice, for the care, transit, housing and killing of research animals. We have two sites in this country: the Marshall Bio or MBR one, and Envigo. If we look across the Atlantic at the USA, one of the Envigo sites in America was closed recently because of gross welfare violations. We were told that when we left the EU, we would level up and have higher standards than anywhere else, but that is very far from the truth and from what seems to be happening.

I am also concerned about how protesters are demonised—as recently as today—even though in this country we have a long tradition of civil disobedience, with the suffragettes, the Levellers, the Diggers and all such things. As a statement of MBR Acres puts it:

“Unfortunately, extremists, including long-time activists, are committing unlawful and dangerous activities each day.”

My constituent, Helen Cheese-Probert, is not what we might call a troublemaker. She is a scientist by training, who came most recently to my surgery on Friday. It is not only her; Ricky Gervais, Will Young and Chris Packham are all on side as well. It is not just the demonisation of protesters that worries me, but the validity of animal experimentation for human conditions. Some figures show that 95% of cases of things done to animals fail to translate to human conditions, so why are we doing it? When our kids are sick, we do not take them to the vet, do we? That stands to reason.

It is time to deploy NAMs technology to its fullest extent and to consign commercial breeding for animal experimentation—it just sounds horrible—to the history books, to the scrapheap or dustbin of the past. When people my age were kids we used to see videos of monkeys being forced to smoke cigarettes, but now we think that is totally barbaric and wrong.

I will end by saying that, as Gandhi put it, the greatness of a nation can be judged by the way it treats its animals. There is a lot of room for improvement and I look forward to hearing what the Minister has to say about fixing this outmoded picture.

[Clive Efford (in the Chair)]

I thank all Members for being incredibly disciplined, as it has made my job very easy. I call Patricia Gibson.

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[Sarah Jones (Croydon Central) (Lab)]

It is a pleasure to serve under your chairmanship, Mr Efford, and to follow the hon. Member for North Ayrshire and Arran (Patricia Gibson), who made a compelling case for putting science first that should guide us all today. I thank the hon. Member for Carshalton and Wallington (Elliot Colburn) for what I thought was an excellent speech, setting out the petition and its aims and the context in which we are having this debate; I also thank the 102,000 people who signed the petition, as other Members have, including the 128 in Croydon Central who did so. As a shadow Home Office Minister, I deal with immigration, police and security. Those issues dominate a lot of our time in this place, and it is good that members of the public push us to talk more about animals and animal welfare, because otherwise, I suspect we would not talk about them nearly often enough.

The e-petition we have debated calls on the Government to ban commercial breeding for laboratories, an issue that the hon. Member for Carshalton and Wallington set out in some detail. As the Labour Front Bencher in this debate, I want to be clear that the Labour party believes that the unnecessary and prolonged suffering of defenceless animals has absolutely no place in a civilised society. That is part of the DNA of our party, and the history of our party is tied to the defence and protection of animal rights.

It is nearly 20 years since the Hunting Act 2004, when the Labour Government ended the cruel practice of hunting with dogs—a clear testament to the progress made since the days of bear-baiting, cockfighting and other awful things. The year 2006 saw the Animal Welfare Act, another landmark piece of legislation that put down serious protections in law for pets, livestock and wild animals alike. We introduced the offence of unnecessary suffering, mutilation and animal fighting, and we promised to end the testing of cosmetics on animals in our manifesto back in 1997.

The last Labour Government were, I like to think, the most animal-friendly this country has seen, and working from the foundations laid by our predecessors, that is what we would hope to be again if we were to get back into Government. This country should lead the world with high animal welfare standards. No animal should suffer unnecessary pain and degradation. It is not a binary decision to be for animal welfare or human welfare; they can and should exist alongside each other. Many hon. Members have set that out very clearly in the debate today.

It is welcome that animal testing practices have improved over many years and advanced over recent years, but as we have heard today we are seeing an increase in testing on some animals. I am concerned about the lack of transparency on animal testing project licence applications as well as the continued permissibility of “severe suffering” as defined in UK law. We heard that in 2021 there were over 3 million procedures involving living animals. Of those, around 1.7 million were experimental procedures on living animals, and the remaining 1.3 million were cases of the breeding and creation of genetically-altered animals. Over 160,000 animals were involved in procedures judged as “severe” or “non-recovery” in terms of harms caused. Some still argue that research on animals is a necessary evil and a key tool for scientific process, but as times, science and views all change, so too must our behaviour.

The Animals (Scientific Procedures) Act 1986, which we have heard much about, is now considered way out of date for modern animal welfare standards and is not properly enforced. We have talked a lot about the 3Rs, and I will not go into more about that now. The development of alternative methods using human cells, AI and modelling techniques was set out very eloquently by many Members, including my hon. Friend the Member for Kingston upon Hull West and Hessle (Emma Hardy) earlier in the debate and my hon. Friend the Member for Bristol East (Kerry McCarthy), who had five very clear action points about the lack of necessity for experiments because of scientific curiosity. We heard much about the alternatives, which are very clear and in many cases much more effective than research on animals.

As the official Opposition and probably with support more widely across the House, we ask the Government to institute a comprehensive review of animal testing with a view to improving practice, limiting animal suffering and increasing transparency, as well as having a long-term objective of phasing out animal testing entirely. The Government must invest more in non-animal technologies as an alternative to animal testing. There are some very sophisticated technologies, as we have heard, which are becoming more sophisticated by the year. They are clearly the future.

The petition refers to licensing. It would be helpful to see greater transparency in the issuing of licences so that the public can see when and why animal testing takes place. According to the 1986 Act, wherever possible a scientifically satisfactory method or testing strategy not entailing the use of protected animals must be used. It is a requirement for those seeking a licence to demonstrate that they considered non-animal alternatives. I wonder if the Minister could clarify how that self-certification is then evaluated and whether licensing applications are assessed by a non-animal methods expert. It is important to understand the scientific rationale behind an application, to understand the procedures and to know that they will have the minimum possible impact on the animal in question. Will the Minister outline the steps that the Government will take to review the system and make it more transparent, and look at licensing applications in the round?

In 2016, Ipsos MORI found that 74% of people believed that more work is needed to find more non-animal alternatives. I am not quite sure why it was only 74%; I suspect it is now much higher. This is clearly a matter of great interest to the public, and this place should respond to what the public are demanding of us in this petition. Many other petitions on animal welfare issues receive hundreds of thousands of signatures each year. We can work harder. I congratulate my hon. Friend the Member for Canterbury (Rosie Duffield) and her all-party group on their work—lots of good work is done across this place—but, as the hon. Member for North Ayrshire and Arran said, there are people in this place who think the status quo is acceptable. What is their argument, what have they got to say and where are they today?

In our opinion, the Government have been dragging their heels on animal issues for years. I would like the Minister to indicate when they will announce a review to identify and eliminate at least avoidable testing, and in the long term testing in its entirety. Will the Government commit to eliminating every unnecessary test? Will the Minister clarify whether the Government are committed to upholding firm standards on animal welfare? We have heard some horrible stories. My hon. Friend the Member for Ealing Central and Acton (Dr Huq) talked about the animal welfare side of things—I have not even touched on that—which is of course incredibly important.

I would be grateful if the Minister can set out where the Government’s views on higher and higher restrictions on animal testing sit in relation to the trade deals currently being negotiated and the post-Brexit world that we live in. We should remain firm in our commitments. We do not want to become more reliant on ingredients and chemicals that have been tested on animals abroad. The offshoring of animal cruelty and poor standards is unacceptable. It would be good to hear from the Minister about that.

Finally, the Minister for Crime, Policing and Fire, the right hon. Member for Croydon South (Chris Philp), answered a written parliamentary question just a couple of weeks ago and said:

“The Home Office assures appropriate protection of the use of animals in science through licensing and compliance assurance under the Animals (Scientific Procedures) Act 1986. This legal framework, implemented by the Home Office Regulator, requires that animals are only ever used in science where there are no alternatives, where the number of animals used is the minimum needed to achieve the scientific benefit, and where the potential harm to animals is limited”—

and that was pretty much a full stop. There was no “We can go further,” “There are things we can do,” or “We can improve.” No inch was given on the status quo. I echo the view across the House that we can do better and go faster. Will the Government commit to that today?

[Clive Efford (in the Chair)]

Minister, there is plenty of time for you to respond, but I would be grateful if you can leave a couple of minutes for Mr Colburn to sum up.