Genetic Technology (Precision Breeding) Bill Debate
Full Debate: Read Full DebateBaroness Bennett of Manor Castle
Main Page: Baroness Bennett of Manor Castle (Green Party - Life peer)Department Debates - View all Baroness Bennett of Manor Castle's debates with the Department for Environment, Food and Rural Affairs
(1 year, 7 months ago)
Lords ChamberMy Lords, in moving Amendment 1, I will speak also to Amendment 2 in my name and briefly comment on the other amendments in this group.
Many Peers will no doubt have received overnight the joint briefing on the Bill from Friends of the Earth England, Wales and Northern Ireland; the Landworkers’ Alliance; the Consortium for Labelling for the Environment, Animal Welfare, and Regenerative Farming —known as CLEAR; the Soil Association; GM Freeze; Organic Farmers and Growers; and the Organic Research Centre. The tone of that briefing reflects what I hear from academics and campaigners: they feel let down by your Lordships’ House. In Committee, we had a detailed, informed and productive debate on the contents of this Bill and the science behind it, and I single out the noble Lord, Lord Winston, for his rich and expert contributions and many amendments. Then they saw the list of amendments for Report, before I had tabled the amendments in my name, and it seemed as though all that debate and all the issues raised in Committee—not satisfactorily answered by the Government—had dissolved into a puff of smoke, or perhaps a puff of gene-edited pollen.
Many Members of your Lordships’ House attended a very informative online briefing on Friday and heard from an academic expert, Dr Michael Antoniou from King’s College London, about his concerns, and I think most noble Lords were copied into the subsequent detailed written exchanges that continued that debate. With that in mind, since Hansard does not yet allow footnotes in speeches, I put on the record two articles that I urge every noble Lord and civil servant who will be involved in this Bill and subsequent regulations to read and ponder: in Nature, on 12 January 2022, “Mutation bias reflects natural selection in Arabidopsis thaliana”; and, in Elementa: Science of the Anthropocene in March 2021, “Differentiated impacts of human interventions on nature: Scaling the conversation on regulation of gene technologies”.
In short, the first is a substantial debunking of the claim that the mutations occurring in nature are random. This is a subject of continuing scientific debate and a claim relied on heavily by the supporters of the Bill, but it is increasingly evidently incorrect. The second makes the point that even if you were to concede that similar detrimental changes take place through natural means, they are not transmitted around the world at the scale of our globalised industrial agricultural systems, which can spread mistakes before they are recognised. Your Lordships will note the date of those articles. The understanding of genetics and particularly epigenetics is changing fast and the Bill is stuck in the understandings of the 20th century.
All the amendments I have tabled, with one exception, offer a final chance: different routes by which your Lordships’ House could take a pause and allow reflection for the science and the understanding to catch up. I think it is telling that in the last few weeks I have had three major groups of scientists from different fields reach out to me to ask for advice on how they can get through to the Government—in the words of one, “to get the Government to understand our issues”.
There is further evidence for that and I will comment further in the next group on government Amendments 3, 5, 6, 9 and 10. These are amendments to foundational elements of the Bill. This is not mere tidying up—crossing the “t”s and the odd dotting of the “i”s. It is reminiscent of the mess we encountered in Committee on the Procurement Bill and the now gutted and apparently defunct Schools Bill. But here we are at the final stage, the last detailed consideration of the Bill, and the Government are still trying to play around with what it is actually all about.
As I said, my amendments—apart from Amendment 12, which is somewhat different—focus on giving us the chance to go slower, to pause, to look at this somewhat differently. In Committee and in the other place, there was much debate about whether animals should be included in the Bill—to draw a parallel, something that, as far as I am aware, is not even being considered in the yet to be settled debate on gene editing in the European Union. It is an issue of great interest to farmers, growers and food manufacturers in the UK—those who are still managing to export there even after Brexit. Noble Lords will see from the briefings that organic growers and farmers in the UK are very concerned about the Bill.
Amendment 27 in the names of the noble Baronesses, Lady Hayman and Lady Parminter, and the noble Lord, Lord Winston—and its associated amendments that make up the rest of this group—sets out a very fast timetable of 2026 for farm animals and 2028 for other animals. The best I can say about it is that it is better than nothing. Should it be put to a vote I will support it, but that is still a very short timetable in view of the time it takes for science to get from the lab bench to the peer-reviewed publication, let alone the time it takes to then reach government understanding.
Amendment 1 excludes animals and Amendment 2 in my name would exclude animals and plants not used for food production. We are told again and again by the Government that they want this Bill for food security—they want to be able to produce food—even though it looks a lot like a Bill designed for and by the multinational-dominated biotech sector. But if it is for food, why allow companion animals—or, indeed, as the noble Lord, Lord Winston, said in Committee, and the Minister admitted, the gene editing of great apes, the species whose closeness to us has been highlighted only this week by research showing we have an embedded understanding of their gestural language?
So, what I have done with my Amendments 1 and 2 is offer the House a final chance to deliver the changes to the Bill that many were expecting. It is not my intention at this point to call a vote on either, unless the House should signal that it does want to reflect, pause and at least proceed more slowly on a major change in our relationship with the natural world—in the natural world—as human animals in an immensely complex system that has developed over hundreds of millions of years.
I understand the point that my noble friend is making. I cited Bos taurus as perhaps the greatest priority in our minds, but I have also mentioned the benefits that would accrue if we could tackle conditions such as PRRS in pigs. He is right that there are other genuses across farm animal species that we must consider.
As I said, we also intend to produce guidance on the animal marketing authorisation process outlined in the Bill. That will include guidance on the evidence that regulations will require to be submitted alongside the animal welfare declaration by the breeder and, if necessary, more specific guidance relevant to particular species. Through that consideration of evidence and clear guidance, we will ensure that the regulatory system works effectively for different species of animals. I hope that the Government’s intended approach, our commitment to phase the introduction of animals under this legislation and the words that I have said from this Dispatch Box are clear and reassuring for noble Lords. I ask noble Lords to consider not pressing their amendments.
My Lords, I thank the Minister for his answer. I thank everyone who has participated in, as he said, this fascinating, detailed and high-quality debate.
I will start with the small bombshell that the Minister that just dropped. We appear to have had a new outline for the way in which the Bill is to be implemented presented to us at the final stage of Report on the Floor of the House—and, as the noble Duke, the Duke of Montrose, pointed out, with some very unclear elements where we suddenly appear to be covering half the cattle but not the other half. I question whether this is the way in which we should be making legislation.
I want to raise a point on something the Minister said which has not been raised before: why is aquaculture here? As the noble Lord, Lord Winston, said, the reality of land animals is that at least you can keep control of them and muster them fairly well. If we include aquaculture in the early stages, we have to realise that once you release something into the sea, as we know from farmed salmon, there will of course be escapes. We have not had a chance to debate all the things the Minister just said.
I want to go back to first principles. I return to the immensely powerful and important speech by the noble Lord, Lord Winston. As he said, he has 40 years’ experience of working with genes. He is your Lordships’ House’s absolute expert. The noble Lord said that we are embarking on a massive experiment with potential global repercussions, but we do not understand what we are doing. Before I go further, I want to put those words to the Minister. My understanding is that the precautionary principle is part of government policy. How does this Bill fit with that principle?
Let me address some of the points that the noble Baroness has made. The Government have always said that our priority for the rollout of this technology will be plants, then animals. I have added to that the reassurance, in frequent meetings that I have held with noble Lords before today, that we can phase that part of it as well. So I do not consider that to be a bombshell.
ACRE, the body that advises the Government on releases into the environment, has recommended that precision-bred organisms pose no greater risk than their traditionally-bred counterparts. Its advice is supported by the Royal Society, the Royal Society of Biology and the Roslin Institute. As for food and feed, consumer safety will be ensured through a case-by-case assessment by the FSA to ensure that products are safe for consumption.
So I hope the noble Baroness feels that his is not a bombshell, that clear processes are involved and that we have been, in every way, precautionary about how we do this. I put it to her that surely it is being precautionary to tackle some of the problems we face. The greatest challenge ever for humanity is to adapt to climate change and to produce food in a way that a modern society, a civilised society, wants—to make sure we address issues such as animal welfare. That is the opportunity of this Bill.
I thank the Minister for his answer. I will pick up that point about animal welfare, and indeed pick up the points made by the noble Lord, Lord Krebs, about pigs in the US that have been gene-engineered—or, rather, gene-disrupted— to make them resistant to porcine reproductive and respiratory syndrome.
This is a case of knocking out one gene in these pigs. We know that any given strain of a virus mutates at a rapid rate—we only need to look at Covid-19. Where we have pigs held in the kind of crowded, dangerous conditions in which we know pigs are held in the US, the virus will mutate very quickly. We have been through this many times. We had it with resistance to pesticides: we got rid of a single disease with one gene and then, of course, it goes. This is the way that biology works, as the noble Lord, Lord Winston, said. We hold those pigs in the kind of crowded, dangerous conditions where PRRS is a concern. Let us remember that this genetic change is only against that one disease. When swine flu arrives, there is nothing in those pigs that will protect them against it, or prevent it becoming a zoonosis and crossing the species barrier into humans. Yet we continue those farming practices.
I pick up the point from the Minister and the noble Lord, Lord Taylor of Holbeach, who said that this is the only way we will feed the world and the only way to get more production. That is what we were saying in the 20th century. The discussion on Friday that I referred is only a preprint, but it reflects the direction of the new biology. The noble Lord, Lord Krebs, said that there is a centre of gravity, but we also know there are tipping points. The new biology acknowledges that a wheat plant and every other complex organism is a holobiont; it operates as a complex of what we think of as the plant, bacteria and fungi that work together. The preprint showed that when a wheat crop is dealing with drought, the epigenetic changes—the kind of changes that the noble Lord, Lord Winston, was talking about, where the plant adapts to circumstances and has its genes expressed in different ways—were happening overwhelmingly in the bacteria and fungi. It is not the genetics of the wheat plant at all. I do not accept that this is the way to feed the world, without tackling the issues of poverty, inequality, food waste and feeding perfectly good food to animals. We need good management of soils and crop diversity—that is how we feed the world.
I feel a sense of despair at this point; I have no alternative but to withdraw my amendment with great reluctance. I really hope that your Lordships’ House has listened, particularly to the speech by the noble Lord, Lord Winston, and that the Government listen to this as we go forward from here.
My Lords, having spoken a great deal on the last group, I will be extremely brief now. What we have is the Government still trying to define what the Bill is about at this incredibly late stage. We have been through Committee, Report and the other stages in the other place and here, and here we are still trying to find the wording. Neither the science nor the law is stable enough for this to become an Act and we have just seen a very useful demonstration in this short debate of how this is very likely to be a field day for lawyers, so the lawyers in your Lordships’ House can get ready.
My Lords, I thank both noble Lords for their contributions to this debate. I particularly thank the noble Lord, Lord Krebs, for his continuing help in trying to get this right. I hope the eyes of not too many noble Lords glazed over. I had to get on the record, about what is undoubtedly a very technical piece of legislation, what we were seeking to do by the changes that we were putting in.
The noble Lord makes a very good point about “modern biotechnology” as a term. I am at great pains not to throw in new definitions that could one day come back to bite us, but “modern technology” is widely recognised to cover a specific set of technologies for regulatory purposes. In particular, it is used in the UN’s Cartagena Protocol on Biosafety. The definition of modern biotechnology can be updated—to be probably even more modern technology—subject to the affirmative procedure under powers in the Bill if required.
I hope that the government amendments, which aim to clarify which kinds of genetic features are permissible in a precision-bred organism and the techniques by which they may be introduced, will provide assurance to the noble Lord not to press his amendments. I hope that noble Lords are confident in accepting these government amendments.
My Lords, in moving Amendment 12, I will speak also to Amendment 13 in my name. This is an adaptation and development of the work done by the noble Lord, Lord Winston, in Committee—he is not currently in his place; I hope he will be back in a second—when he put forward the idea of a register. This is my attempt to write that register into the Bill, to establish full transparency and traceability around gene editing.
The drafting is my own, although I thank the Table Office for its help. I will not claim that this is the perfect way to set this in the legislation, but in this legislation it absolutely should be, for the sake of transparency and traceability. We are giving commercial companies the right to mess around with the basis of life on earth. Showing their working and allowing the knowledge to be available to others is a small price to pay.
The noble Lord, Lord Krebs, and I had a detailed debate in Committee about whether it is possible to identify gene-edited organisms; some aspects of that debate remain in dispute, but we heard on Friday’s call that, should the nature of the gene-editing event be recorded, as Amendment 12 calls for, there is absolutely no doubt that any gene-edited organism can be identified.
This amendment goes further in calling for the record of the whole-genome sequence of the qualifying organism to be recorded. For the House’s information, I think it is worth going a little further into that, and into an explanation of why the regulations should be covered by the affirmative procedure.
Whole-genome sequencing can accurately identify the full spectrum of unintended mutations at both off-target and on-target editing sites, including the inadvertent insertion of foreign DNA. Given what we heard from the Minister in the last group, I am not sure how we can be sure than an organism is legal if we do not have this. Multiple-reference genomes derived from the whole-genome sequencing of major crop plants are available already in the public domain. That has yielded important information about the unintended effects of gene editing on the genome. For example, in a study on gene-edited rice using CRISPR-Cas, whole-genome sequencing was used to investigate unintended mutations arising from several aspects of the gene-editing procedure. The procedure, which taken as a whole includes tissue culture and Agrobacterium-mediated cell transformation, resulted in several times more unintended mutations than were found in rice propagated through natural pollination. If you do not do the whole-genome sequencing, you simply cannot know that to be the case.
We are sometimes told that this is too complicated, difficult and expensive. We have been talking about how fast this field is moving, and one recent innovation is what is known as long-read DNA sequencing. Unlike many things in this area, its meaning is pretty clear-cut from its self-description. It provides a continuous sequence that reads up to 1.5 million DNA base units and would provide unequivocal understanding of the placement of long stretches of repeat sequences, which some of the older methods that break up the DNA strand do not do so easily. Several companies offer a long-read genome sequencing service, making this technology readily available.
I did not write this into the Bill, and it is another reason why I put in the affirmative procedure, but this register could also include requirements for molecular compositional profiling methods: gene expression-profiling transcriptomics, protein-profiling proteomics and small biochemical molecule-profiling metabolomics—let us call them “omics”. These are now used by thousands of research groups around the world to gain a more comprehensive and deeper insight, not just into the genome but into how an organism functions. It is crucial to understanding the health and disease implications of the genome to see how that genome plays out in the proteins in the cells.
A 2016 research paper published in the extremely prestigious journal Nature used a multi-omics approach to demonstrate that a glyphosate-tolerant GM maize was not substantially equivalent to its non-GM relative. The large-scale protein and metabolite alterations that were detected were unintended consequences of the GM transformation process, with potential downstream health consequences for the consumer in terms of the introduction of toxins and allergens.
I see that the noble Lord, Lord Winston, is here and I refer Members of your Lordships’ House to his speech in this area and our discussion in Committee. To know what is going on is scientifically and practically essential. That is why I have tabled these amendments. I do not intend to move to a vote, but this is a matter that the Government should commit to. It is interesting that in our discussion on Friday with all the experts one of them said to me, “Yes, there is a public register. At least that’s how it’s going to work”. I do not know whether the Minister can explain this, but my understanding is that there is nothing in the legislation that provides for a public register. If I am wrong, I am happy to be corrected. However, these people are proponents of the Bill and this procedure, and they believe that there will be a public register. If that is what the experts are trusting in and want to be able to use—it is a public resource—and if it is not already there, the Government certainly should introduce it. I beg to move.
I thank the noble Baroness, Lady Bennett, for introducing the amendment because it gives me a chance to say two things quickly. One, which she alluded to, is our discussion in Committee about detectability by analytical methods. I asked Wendy Harwood from the John Innes Centre to give me an exact form of words about that, which I shall repeat with her permission. It confirms, in a way, what the noble Baroness has just been saying. Wendy Harwood said:
“If you had details of the exact edit made, then you could detect”
the PBO by polymerase chain reaction,
“followed by sequencing of the PCR product. If you were just presented with a plant, and no audit trail and asked whether it was genome edited, you could not determine whether it was or not.”
One therefore needs an audit trail in order to be able to tell. She continued:
“If exactly the same change had been made by precision breeding as had been made by traditional breeding, and you tested by looking for that precise change, then you would not be able to tell which was which. Again an audit trail would be required. You might however have a case where both PB and traditional breeding had made changes to the same gene, giving the same trait, but these changes were not identical at the DNA level, in this case you could tell the difference.”
That emphasises that if one is serious about knowing which products on the shelves are produced by PB, there needs to be an audit trail.
On whether whole-genome sequencing is of value, one angle is that so much mutation in the genome is going on all the time that it is hard to know what one’s reference material would be. The Royal Society produced in its evidence to the Defra consultation a calculation that in a hectare of wheat there would be at least one mutation for every base pair in the wheat genome. There are 10 billion base pairs in a wheat genome. In a one-hectare field of wheat, there would be a mutation somewhere in every one of those base pairs. So the difficulty with using whole-genome sequencing is what one makes of the information one gets. There will be huge variation and one does not quite know what the value of the information is.
I think we have agreement that some parts of the genome are functionally relevant and have a particular functional significance. We perhaps have points of disagreement about how relatively protected some of those may be from natural mutations. There are lots of mutations that happen naturally in areas that may be beneficial to the plant but only in certain parts of the genome and with certain sorts of functional effects. The parts of the genome that are particularly crucial to the function of the organism are the structural, basic ones, where there are far fewer natural effects. If you read the complete list of the genome, you are going to look at certain bits to see which changes are significant, which ones may be deleterious and which ones are less significant. Does the noble Lord agree?
My Lords, I thank the Minister for his answer, and everyone who contributed to this debate. Once again, the noble Lord, Lord Winston, gave us the expert nailing of the issues. I thank particularly the noble Baronesses, Lady Bakewell of Hardington Mandeville and Lady Hayman of Ullock, for stressing the importance of transparency, both for scientific and public confidence reasons.
The Minister went over some of the same ground that the noble Lord, Lord Krebs, and I circulated back and forth on in terms of saying “Oh, there are lots of mutations” is not a reason not to do whole-genome sequencing. What we see are the mutations that are of greater importance in particular areas of the genome, et cetera, so the claim that “Oh, there are lots of mutations, so it doesn’t matter” does not scientifically stack up.
We are in a situation of regulations. The Minister said that the regulations will specify that the release notices contain “relevant and necessary” information. I think it is already clear that the detail of what “relevant and necessary” actually means is going to be crucial. We all know the problem with regulation and the way in which we are given it on a take it or leave it basis. Again, I feel great reluctance: I feel that we really should have whole-genome sequencing, and indeed broader omics testing. But I see no option at the present moment but to withdraw the amendment, with great reluctance.
My Lords, I am aware of the time but I have attempted, through this amendment, to find a creative new way of tackling some of the issues that have come up in the Bill. The noble Baroness, Lady McIntosh, said quite some time ago, early on, that we have to reassure the public. The noble Lord, Lord Trees, said in the last debate that it is essential to take the public with us. The Minister said that it is essential to build confidence. This amendment seeks a positive way forward. For anyone still worrying about their dinner break, I am not intending to put this to a vote, for the avoidance of doubt, but I want to suggest a way forward for what has clearly been a very difficult Bill with a lot of issues that remain of great concern in your Lordships’ House and more broadly.
On the first group, I spoke about the number of people whom I know are watching the debate at this very moment and feeling very disappointed about what has happened—or rather, not happened. I also refer back to what I said at the start about the scientists who were coming to me saying, “How do we get our knowledge through to the Government? We feel we are just not being heard”, and these are experts in a range of different fields. This is a creative suggestion. I might have included the word “consultation” but, as we have heard in debates on various amendments today, the Government did consult the public and stakeholders and then entirely ignored what they said. It might be said with some justice that what result you will get depends on how you ask the question. Indeed, I think the Minister at some stage referred to a survey saying, “If we can get drought-proof wheat with gene editing, should we go ahead with it?” If you phrase the question that way, you will get a positive result; however, that is not listening to the academic—a proponent of the technology—who said to me this week, “You cannot drought-proof wheat with one genetic change. That is a fact.”
What I am suggesting here is a process of deliberative democracy. This is something that has really taken hold in government departments—not, that I know of, in Defra, but in others—and indeed across the world. Some of the classic examples of deliberative democracy are in Ireland, on equal marriage and on abortion, where the public, when allowed a chance to deliberate and carefully consider the issues, showed themselves to be significantly in front of the politicians. We have seen climate assemblies in the UK— that may have been under Defra; I am not sure what department they were under. We have seen a very effective climate assembly in France. Lots of local government organisations have been having climate assemblies. It is a way of getting people together and getting themselves informed, both the general public and stakeholders.
I borrowed the term “priority setting partnerships” from an organisation called the James Lind Alliance; I did not ask first. I have spoken to people who have been involved in this process, and it is of particular relevance here because it has been used in a significant number of cases to look at how to set priorities and make decisions about ways forward in healthcare. It brings together clinicians, patients and carers in those healthcare settings. My Amendment 28 is a commencement amendment, but I am not going to push it on that basis. My constructive suggestion to the Minister is that, to find a way forward among many of the issues that have really not been resolved in your Lordships’ House, and have not been resolved among scientists, the Government should seek a deliberative process looking at how the regulations are constructed for the Bill. That process could actually get public involvement and engagement, because I guarantee him that there will be a great deal of public concern and public anger about where we have got to today, and public resistance to the products.
That issue is particularly going to arise around whether gene-edited products will be labelled. I could very easily have tabled amendments on this; lots of people asked me to. We debated it extensively in Committee, but I could not see a different way forward and I did not simply want to revisit the Committee debate. However, if we are going to talk to the public about labelling and about what is happening to their food, we know how deep the public’s concern is about food safety, the nature of their food and the way it is produced. I do not need to list all the scandals and the concerns, including genuine health concerns, that have arisen in recent years. This is an area of public concern, so I am suggesting that on regulations, issues such as labelling and many of the things that remain unresolved, the Government should bring together scientists, government officials, experts and the public and seek a way forward that works.
While I remain gravely concerned, for all the reasons I have set out previously about the Bill and what it could unleash, I think there is a very significant chance that this will go nowhere, both because of the legal tangles and the public resistance. If the Government want to find a constructive way forward, I have set out here a way in which they could co-create a model with the public and the experts. That is my genuinely constructive suggestion, and I beg to move.
My Lords, if Amendment 28 is agreed to, I cannot call Amendments 29 and 30 for reasons of pre-emption.
I thank the Minister for his answer. I will certainly look to take up his offer in the final section of his response. I also thank the noble Baronesses, Lady Bakewell of Hardington Mandeville and Lady Hayman of Ullock, for acknowledging the reasons why I brought forward the amendment and the continuing issues around the Bill, that, I think, the Minister also acknowledged to some degree.
I make one comment on the Minister’s reliance on ACRE, which has an extremely narrow scientific focus that lacks the sociological and ecological approaches that would give the Government a much broader view. The noble Lord, Lord Krebs, and I were playing with metaphors around centres of gravity and shifting balance. ACRE reflects one part of the scientific community and views, but not perhaps the more, dare I say, modern and newer forms of biology, which are not represented in its membership.
However, we are where we are, and I feel the next debates pressing in on us. We have had a good debate today. I do not think we have got to where we need to go, but I do not think we are finished on this issue by any means. In the meantime, I beg leave to withdraw my amendment.