Question to the Department of Health and Social Care:

To ask His Majesty's Government what guidance NHS England provides to people who are prescribed antidepressants on the risks of developing persistent genital arousal disorder (PGAD); and what consideration NHS England has given to adding PGAD as a side effect on the patient information leaflets for any medications which can cause it.

The Medicines and Healthcare products Regulatory Agency (MHRA) is an executive agency of the Department with responsibility for the regulation of medicinal products in the United Kingdom. The MHRA ensures that medicines are efficacious and acceptably safe, and that information to aid the safe use of a medicine, including possible side effects, is appropriately described in the authorised product information.

The MHRA’s approved patient information leaflets for the most commonly prescribed antidepressants contain warnings about sexual side effects whilst taking the drug, and for some antidepressants there is a warning about sexual side effects which may continue after stopping the medicine. These warnings are under review by an expert working group of the Commission on Human Medicines, and the findings of this review are due to report in the Autumn.

Persistent genital arousal disorder (PGAD) is not specifically listed as a possible side effect in the patient information leaflets for any antidepressants. PGAD remains poorly defined and requires research into several proposed causal factors.

A total of 13 reports that describe PGAD suspected to be associated with an antidepressant have been received through the Yellow Cared scheme. The reports were received between 2017 and 2025 for sertraline, with six reports, citalopram, with three reports, fluoxetine, with three reports, and reboxetine, with one report.

The MHRA continuously monitors the safety of these medicines. However, the data currently available is considered insufficient to list PGAD as a possible side effect of antidepressants. Any emerging data will be carefully considered and regulatory action taken as needed.