Question to the Department of Health and Social Care:

To ask the Secretary of State for Health and Social Care, pursuant to the oral contribution of the Minister of State for Health and Social Care on 17 June 2025, Official Report col 352, what his planned timescale is for a decision of the NHS England Clinical Priorities Advisory Group in relation to commissioning of abiraterone acetate plus prednisone for hormone-sensitive non-metastatic prostate cancer, following the sharing of updated cost impact modelling from Prostate Cancer UK.

In regard to funding for abiraterone specifically, abiraterone is not licensed for use in the treatment of high-risk, non-metastatic hormone-sensitive prostate cancer, and as such cannot be evaluated by the National Institute for Health and Care Excellence (NICE) for routine use on the National Health Service. NICE makes recommendations for the NHS in England on the vast majority of new medicines and significant licence indications for existing medicines, but does not evaluate medicines that are used outside their marketing authorisations or “off-label”.

Funding decisions for off-label medicines are the responsibility of NHS commissioners, who are required to make decisions on the basis of the available evidence. For cancer medicines, NHS England is the responsible commissioner and has an established mechanism to do so through its clinical prioritisation process. NHS England considered abiraterone as an off-label treatment for the treatment of hormone sensitive, non-metastatic prostate cancer through its clinical policy development process in 2024/25. Through this process, NHS England confirmed that there was sufficient supporting evidence to support the routine commissioning of abiraterone in this indication and it was ranked as the top priority for routine commissioning. However, NHS England has not been able to identify the necessary recurrent funding to support the commissioning of abiraterone, or any other treatments within the prioritisation round. This position in being kept under review and will be progressed as soon as recurrent funding is identified.

This position takes into account the need to ensure the affordability of introducing any new routine commissioning policies, alongside maintaining existing services for patients, and of meeting their legal requirement to fund all NICE approved drugs. Abiraterone for the treatment of high-risk, hormone sensitive, non-metastatic prostate cancer remains the top priority for routine commissioning.