Genetic Technology (Precision Breeding) Bill

Katherine Fletcher Excerpts

2nd reading
Wednesday 15th June 2022 Commons Chamber

[Katherine Fletcher (South Ribble) (Con)]

I am speaking today in full support of the Bill, precision breeding and our outstanding scientists, who are looking to this House to unlock barriers to solving many of the most important problems facing us on earth. I want to see this Bill unleash their capability and energy on those problems, and I hope to be supporting the Bill throughout the whole of its passage.

Let me explain why I stand up with this bouncy enthusiasm. To take the House back to the 1990s, when I was young and thin, I was honoured to be at the Nottingham University life sciences department doing a biology degree. If the House will bear with me, I have a little practical knowledge of DNA editing techniques, as my undergraduate paper was using transgenic Caenorhabditis elegans as a biological monitor for freshwater sediment toxicity.

[Dr Hudson]

Hear, hear!

[Katherine Fletcher]

Quite. That is a mouthful, but the key here is “transgenic”. We were putting a gene from Escherichia coli—E. coli—into an itty-bitty nematode worm, an animal, and making a cross-species C. elegans. Those little guys were effectively harnessing natural stress repair mechanisms to produce something that we could measure easily.

I was a scientist; I was fascinated by that, but it did not always sit brilliantly with me, and the mechanisms that were used to produce that transgenic environment were at best embryonic and new. It was effectively taking DNA material in vectors such as plasmid, and pebbledashing a target DNA area. We did not know where it was going to land, and we had a lot of wastage where bits of DNA were going in the wrong place. That is not what the Bill is about, and I look forward to going into that in more detail.

[Dr Hudson]

We have heard concerns that people feel that an exogenous species of DNA would be coming in. Does my hon. Friend agree that this technology is not about that? This is not about an external species coming in, and perhaps the Bill could be tightened up by clarifying that, which would appease some of people’s potential fears.

[Katherine Fletcher]

Yes. If the Bill contained a way of opening up the transgenic debate, be that in plants or animals, it would not enjoy my support.

While I have put on a lot of weight since the mid-1990s, science has also massively moved on. In response to the intervention by the hon. Member for Brighton, Pavilion (Caroline Lucas), this is a bit like comparing a 1997 diesel car with modern zero-emissions vehicles. Yes, they both have wheels, go along in a straight line and are called cars, but the two things are completely different. The British public were right to be cautious at the time, but let us explain why this is different. We now know the genome sequences of other target species and plants, and we have exact tools that are effectively like clever genetic snippers that will go along a genome and only cut in the exact place. There is confidence and science behind that point. We then insert something that, as my hon. Friend the Member for Penrith and The Border (Dr Hudson) highlighted, comes from the same species. If we have wheat that does not taste nice but is good at growing in dry conditions, why can we not give it that dry condition gene, so that it tastes nice and is nutritious and can help feed the third world? There are scientists chomping at the bit to have a go at that—I really cannot wait.

As part of my undergraduate degree I went to Rothamsted and saw the scale that has to be put in place for traditional breeding techniques—think fields and fields and fields. Variant 1 has been crossed with variant 2 in a modern way, but it then needs to be tested, because in traditional breeding techniques we basically take the whole genome, throw it up in the air and ask nature to pick one variant out of two. That means we are looking at multiple generations to try to keep the tasty wheat, as well as the dry, coarse wheat. This is a fantastic opportunity to use fewer resources while doing that research, and to use fewer resources from the environment.

Let me highlight some of the extremely exciting opportunities that I have pulled out of the literature: disease-resistant wheat that needs less pesticide, as mentioned by the Secretary of State; tomatoes with a little extra vitamin D; wheat with reduced asparagine to ensure that people are not exposed to carcinogens, especially if, like me, they cannot cook properly and always burn everything; or chickpeas with high protein levels that help those who are making an environmental choice by being vegan or vegetarian. The possibilities for health, climate, environment, farming and our planet are as endless as the natural variation within species that had Darwin so fascinated. We must do this, and I totally support the Bill.

[Deidre Brock (Edinburgh North and Leith) (SNP)]

The regulation of genetically modified foods is a devolved issue. It is important to emphasise that at the start because, as in a growing number of policy areas, the UK Government pay only lip service at best to the powers exercised in the Scottish Parliament, while at the same time running roughshod over devolution with their post-Brexit deregulatory agenda.

Although the intended scope of the Bill may be England only, it is explicit that it will have significant impacts on devolved areas. The devolved Administrations were, however, only informed of this just one day before the Bill was introduced, in a letter from the Environment Secretary encouraging them to adopt the Bill’s principles. A UK-wide approach can, of course, sometimes be desirable, but this invite creates an illusion of collaboration and choice when in fact DEFRA is acting unilaterally once again. Frankly, it smacks of contempt for our democratically elected Government.

If the Scottish Parliament refused to allow gene-edited crops to be planted in Scotland, we would still be prevented from stopping GMO products from being sold in our shops under the devolution-violating United Kingdom Internal Market Act 2020. This is exactly the kind of scenario the SNP warned against when the Tories forced that legislation through this place. I understand that DEFRA officials have now suggested that the Department discuss the UK Government’s plans to diverge from the common UK-wide GM regulatory regimes. Well, thanks very much, I am sure, but any discussions of that nature should have taken place prior to the introduction of the Bill so that potential policy divergence could be properly considered. The fact that they have not is deeply regrettable and unacceptable.

The SNP is committed to ensuring that Scotland operates to the highest environmental standards, and that we protect and enhance the strength of Scottish agriculture and food production. If we end up with unwanted gene-edited products in Scotland, diverging standards with the EU could cause further damage to our sales, risking damage to Scotland’s reputation for high-quality food and drink.

[Katherine Fletcher]

The way the hon. Lady is talking about gene editing implies that one can tell the difference. It brings in variant genes from the same species. It is literally scientifically impossible to identify a gene-edited product if it is done properly.

[Deidre Brock]

I accept the hon. Lady’s experience in this area, but there are many scientists who would differ from that opinion.

--- Later in debate ---

[Caroline Lucas (Brighton, Pavilion) (Green)]

I believe that this is a flawed Bill—it is not strategic, it is not clear and it does not do what it says on the tin. Ministers breezily assert that it will deliver access to wonderful new markets, while failing to acknowledge that it actually risks hindering access to our closest significant market, the EU, as we create a divergent regime for regulating genome-edited products. As we have heard, consequences for trade with Northern Ireland are being ignored. With the Scottish and Welsh Governments currently taking a different approach from that of England, the Bill is a recipe for consumer confusion and significant operational difficulties for retailers across the UK.

These big questions are critical, but in the short time that I have, I shall spell out how the Bill falls down on some core principles that render it flawed and not fit for purpose. Those principles are scientific coherence and clarity, properly defined criteria—or the lack of them—and transparency.

On coherence and clarity, in its title and text the Bill uses the phrase “precision breeding”, yet that is neither a specific technology nor a scientific discipline. It is a marketing term: a vague colloquialism for a number of recently developed genetic engineering technologies, which do not form a coherent group of methods, and do not justify being called “precise”—not when the scientific literature contains reports of genetic technologies such as genome editing creating unexpected and unwanted mutations, genetic errors, altered proteins, and extensive deletions and complex rearrangements of DNA in plants. [Interruption.] I will not give way yet.

The Government give a nod to that uncertainty with their caveat that genetic editing of animals will not take place until animal protection can be safeguarded. Engineering the DNA of animals raises major animal welfare and ethical concerns. A wealth of problems are set out by the Nuffield Council on Bioethics report on gene-edited farm animals. As I understand it, there is nothing to prevent biotech-created disease resistance being used as a sticking-plaster for the intensive factory farming practices that are the underlying cause of disease emergence in the first place. That is why, given the current drafting, animals should be removed from the Bill’s scope, full stop.

[Katherine Fletcher]

Nature makes mistakes; that is how evolution comes about. So the mistakes that are reported in the literature are actually further evidence that such technologies effectively replicate a natural process. Does the hon. Lady agree?

[Caroline Lucas]

I thank the hon. Lady for her intervention. As has been said, she clearly has expertise, but I am looking at the scientific evidence that has been put before me, and it is being suggested that the mistakes that can be made in this area, especially when it comes to nature, appear very different from those that are seen in nature.

I move on to the principle of properly defined criteria. Using a term that lacks any proper definition looks like an attempt to obscure the full scope of the proposed deregulation. The terms “precision breeding” and gene editing help promote a particular narrative—that the process is just a simple “cut” or “tweak”. The Government are also at pains to stress that any changes might have occurred “naturally” and do not involve the insertion of transgenes—so-called “foreign” DNA.

I have read that this is to some extent smoke and mirrors. The Bill seeks to deregulate all manner of genetic manipulations, and genome editing can sometimes involve the insertion of foreign DNA. As I understand it, the argument is that in such cases the inserted DNA gets removed before the product goes to market. That may well be the intention; but by using poorly defined criteria in the title and wording of the Bill, the Government are asking us to pass bad legislation.