Animal Testing

Andrew Griffith Excerpts

Monday 19th February 2024 Westminster Hall

[The Minister for Science, Research and Innovation (Andrew Griffith)]

It is a pleasure to serve under your chairmanship, Dame Caroline, and I thank my hon. Friend the Member for Carshalton and Wallington (Elliot Colburn) for opening today’s important debate. As this is the first time I have spoken since, let me also commend him for his personal bravery when he spoke at the most recent Prime Minister’s questions.

The number of signatories to these petitions—I think almost all hon. Members have mentioned it—indicates the strength of public feeling on this matter. This is not the first time that this issue has been debated, although it is my first time. Although I think none of us would want such a debate to become an annual event, this is absolutely the right forum in which to debate these important matters. I therefore congratulate all those who have contributed and everybody who has signed the petitions.

I completely understand that the use of animals in science, including in toxicity testing, is a sensitive issue. More than that, I believe that everyone here would share my view that the day cannot come quickly enough when we are able to end the practice of animal testing. It is to hasten that moment that, as hon. Members have observed, the UK is one of the world’s leading nations in the development of non-animal methods. The Government are keen to ensure that those are utilised wherever possible, and I heard some frustration or concern from colleagues about the pace of adoption where the scientific methods exist. It is fair to say that most hon. Members accept—I have met charities and organisations working in the sector, including Animal Free Research UK—that we are not quite at that moment when we can fully replace animal testing.

To a degree, we are all in what my hon. Friend the Member for Chatham and Aylesford (Tracey Crouch) eloquently called that “mess of complexity”, but that does not mean that we are not clear about the direction of travel and the goal that we seek over time. As the Science and Research Minister, I take extremely seriously my responsibility within the multiple Departments that my right hon. Friend the Member for Camborne and Redruth (George Eustice) talked about.

The Government are supporting and accelerating advances in biomedical science and technology to reduce reliance on the use of animals in research. When we hear data points about the percentage of research money that is spent, it is important to remember that not all of that research is clearly labelled as non-animal research. Developments in respect of artificial intelligence, cell cultures, cell research, understanding the function of human organs, and better imaging can all contribute to the advance of non-animal methods that can be put to work in this space. Indeed, we heard from the hon. Member for Newcastle ex vivo analysis upon Tyne Central (Chi Onwurah) about the very successful spin-out from her university, and we are seeing that sort of development elsewhere. As my right hon. Friend the Member for Camborne and Redruth said, the rate of growth has been exponential, and this is an amazing moment in science of all kinds. There have been extraordinary advances in non-invasive techniques, such as medical imaging, sensing and ex vivo analysis, which are revolutionising human healthcare.

Through UK Research and Innovation, the Government are actively supporting and funding the development and dissemination of the three Rs, and I will have more to say about that later. Anyone who was not familiar with the three Rs when they came here today is probably more familiar with them now. They stand, first, for the replacement of the use of animals where it is not necessary for research, which I think is the aim we all share. Then, there is the reduction in the use of animals in the meantime, and the latest figures I have, which are slightly more recent than the ones my hon. Friend the Member for Carshalton and Wallington referred to, show a 10% reduction in the use of animals in research. I do not want to over-weight any particular year’s numbers, and we will have to look through and see the continued reduction we all seek. However, the latest data I have, for 2022, showed a 10% reduction. Finally, in addition to replacement and reduction, there is refinement to eliminate or reduce distress to those animals that are involved. All of that is achieved primarily, but not exclusively, through the approximately £10 million of funding per year that goes to NC3Rs, the national centre for the three Rs. We heard of other examples, including Queen Mary University of London’s centre for animal research, which is also doing great work in this area.

We have also heard that the use of animals in science lies at the intersection of two important public goals. There are the benefits to humans and animals—a lot of the research benefits animals themselves—and to the environment, as we seek to have the very highest standards of environmental protection. But we must also balance that with the UK’s proud commitment to the highest possible levels of animal welfare. That is why, as we heard from a number of Members, the use of animals in testing is strictly limited to specific purposes, including assessing the safety of medicines or chemicals, protecting human health and protecting the environment—a lot of research goes on into compounds to understand their downstream effect on our rivers, lakes, oceans and natural habitats.

We also heard that the use of animals in scientific procedures is permitted only if there is no non-animal alternative available, and I will try to address some of the remarks that have been made specifically about the way in which that legal principle, laid down by Parliament in legislation, is applied in practice and whether it is as effective as my right hon. Friend the Member for Camborne and Redruth would like.

Despite the general legal protections, some animal testing of chemicals is required under UK law to protect the environment, but such testing is permitted only once it is established that no alternative exists, and it is dependent on the chemical and quantity being manufactured.

As I said, we are world-renowned for our leadership in this space, and we should continue to be alive and open to what other countries are doing. The example of Canada was mentioned, and some of the work I have done and the meetings I have had have focused precisely on how we can ensure that the UK remains the best place in the world in terms of the legislative framework and the science and how we can ensure that non-animal technologies and the constant advances in them are reflected in policy, practice, legislation in this place and animal research regulations.

Since it was established, the NC3Rs has invested in total almost £90 million in research and £27 million in contracts through its CRACK IT Challenges innovation scheme for UK and EU-based institutions, with that funding mainly focused on approaches for safer assessment of pharmaceuticals. The UKRI Biotechnology and Biological Sciences Council—a different body—supports research aimed at developing and applying innovative methods to study human and animal physiology, including in silico approaches, organ on a chip, and organoid and other advanced cell culture systems.

Despite that funding, I believe that more can be done. Ahead of today’s debate, I asked UKRI that we double our investment in research to achieve the three Rs and develop non-animal alternatives. I can announce that, from £10 million this year, that investment will reach £20 million per annum across the system in fiscal year 2024-25, which is a doubling of what is given to research in this space. In addition—I hope this is welcome across the House—I can announce that this summer, following on from work done by my predecessors and across other Departments, the Government will publish a plan to accelerate the development, validation and uptake of technologies and methods to reduce reliance on the use of animals in science. The former Minister, my right hon. Friend the Member for Camborne and Redruth, will recognise some of the impedance on a Minister at the Dispatch Box, but I can see no reason why that plan could not at least consider some of the machinery-of-government changes that he talked about.

[George Eustice]

I think everyone will welcome the significant increase in funding that the Minister has pledged today to support research on non-animal methods, but is his Department at all curious why the number of animals used in experiments has not gone down, despite huge increases in technology in this area? As part of a review of the licensing process for projects, would he consider trying to get us some analysis of whether the decision to grant a licence is objective, or subjective and based on something that some ethical committee claims?

[Andrew Griffith]

My right hon. Friend makes a very good set of points, and that is something that we will look at further. I am already in discussion about the efficacy of the licensing regime with the noble Lord Sharpe, who is the Home Office Minister responsible.

[Patricia Gibson]

As the Minister stands here today, how confident is he that the regulatory bodies that monitor these matters are sufficiently well versed and up to date with placement and reduction opportunities to prevent unnecessary testing? Does he have confidence in that system?

[Andrew Griffith]

The hon. Lady asks a very detailed question, and she has made some statements that I would like to verify anyway. I was concerned to hear about dogs being shot or blown up and I would ask her, if she has evidence of that, please to share it with me. That would be a subject of great concern and perhaps bring to life some points in the regulatory system that have not crossed my desk to date. I take that matter very seriously, but it is also important that these debates are led by the facts, and I will let the facts decide the efficacy of the regulatory system.

We will produce the plan together with not only officials but the very widest group of stakeholders. In the coming weeks, a cross-Government group will convene to lead that work, and we will consult stakeholders across the industry, academia, medical research charities and those operating in this space. The commitment is to publish that detailed plan this summer.

Given the support for the petitions and the strong interest in this issue, on which Members of Parliament are regularly petitioned, I can announce today that we will restart the public attitudes to animal research survey, which was unfortunately delayed during the pandemic. It is important to me, and I am sure to the House, that these debates are informed by that survey. It was seen as a very useful tool for those working in this space, and I am keen that it is restarted. The next survey will take place in the coming months and the results will be published this autumn, restarting that chronological series about public attitudes.

We talked about how animals in science are highly regulated, and I hear the concerns about that process. Understandably, as with any regulatory process, different people will have different views about efficacy. There is a three-tier system of licensing, at the establishment, project and individual level. Again, I thought that my right hon. Friend the Member for Camborne and Redruth made a very thoughtful contribution; perhaps I will meet him to benefit from some of his insights on that. He talked about the importance of having qualified vets in the process. It is important to say that there are qualified vets, and the Animals in Science Committee oversees that process and advises the Home Office on it.

However, endemic in any regulatory or licensing regime is the danger—I do not say that this is indeed the case— of incumbent thinking. My right hon. Friend talked about there not being enough challenge in the process. One potential way of putting in more challenge—or nudging—is increasing the fees for licences, which the Home Office is going to do shortly. My right hon. Friend talked about a levy. This is not a levy, but by increasing the fees, and therefore the burden, we will perhaps shift some of the presumption away from defaulting to testing with animals.

In addition, the Home Office will review the duration of licences. The current duration is typically five years. We have observed the fast rate of change in technology. The Home Office will review the duration to see whether a shorter licence period would be more appropriate, and whether people coming back more often would put more challenge into the system.

In conclusion, I want to be clear: it is the Government’s position that we want to replace the use of animals in scientific procedures with non-animal alternatives wherever we can. For now, the carefully regulated use of animals in scientific research remains necessary if we are to protect humans and the wider environment. That is why our current approach is to continue to support and fund the development, dissemination and adoption of techniques that replace, reduce and refine the use of animals in research, and to ensure that the regulatory framework is both robust in law and rigorous in practice. I thank hon. Members for their insightful and thoughtful contributions to today’s debate, and I look forward to working together going forward.