Question to the Home Office:

To ask the Secretary of State for the Home Department, pursuant to the Answer of 23 January 2025 to Question 24409 on Animal Experiments: Dogs, what the evidential basis is for stating that tests of procedures on dogs predict the safety of conducting the equivalent procedures on humans with up to 96% accuracy.

The evidential base is from an international consortium of large pharmaceutical companies, and published in the journal: www.sciencedirect.com/journal/toxicology-and-applied-pharmacology. The specific paper provides an industry-wide translational database of animal to human outcomes and examines the concordance between humans and dogs, non-human primates and mice.

The full citation is: Monticello TM, Jones TW, Dambach DM, Potter DM, Bolt MW, Liu M, Keller DA, Hart TK, Kadambi VJ. Current nonclinical testing paradigm enables safe entry to First-In-Human clinical trials: The IQ consortium nonclinical to clinical translational database. Toxicol Appl Pharmacol. 2017 Nov 1;334:100-109. doi: 10.1016/j.taap.2017.09.006. Epub 2017 Sep 8. PMID: 28893587.