Question to the Department of Health and Social Care:

To ask the Secretary of State for Health and Social Care, what steps his Department is taking to ensure sufficient supply of (a) creon and (b) other ADHD medications.

The Department has been working with suppliers to address current supply issues with pancreatic enzyme replacement therapy (PERT) used by patients with conditions such as cystic fibrosis and certain cancers, including pancreatic cancer. The supply issues are impacting countries throughout Europe and have been caused by limited availability of raw ingredients and manufacturing capacity constraints to produce volumes needed to meet demand. The Department is continuing to work with all suppliers of PERT to help resolve the supply issues in the short and longer term. This includes asking that they expedite deliveries, source stock from other markets, and increase production.

We have issued comprehensive guidance to healthcare professionals about these supply issues, which provides advice on how to manage patients whilst there is disruption to supply. This guidance is being kept under review and updates will be made as necessary. Serious Shortage Protocols are in place for Creon 10,000 and 25,000 capsules to limit prescriptions to one months’ supply whilst stocks are limited.

The Department has also been working hard with industry to help resolve supply issues with some attention deficit hyperactivity disorder (ADHD) medicines, which are also impacting countries throughout Europe. As a result of intensive work, some issues have been resolved. All strengths of lisdexamfetamine, atomoxetine capsules, and guanfacine prolonged-release tablets are now available. We are working to resolve the remaining issues impacting some strengths of methylphenidate. This includes asking suppliers to secure additional stocks, expedite deliveries where possible, and review plans to further build capacity to support continued growth in demand for the short and long-term.

The Department has worked with specialist clinicians to develop management advice for clinicians which includes consideration to prescribe available alternative brands of methylphenidate prolonged release tablets. We have widely disseminated our communications and continually update a list of currently available and unavailable ADHD products on the Specialist Pharmacy Service website, helping to ensure that those involved in the prescribing and dispensing of ADHD medications can make informed decisions with patients.