Question to the Department of Health and Social Care:

To ask the Secretary of State for Health and Social Care, with reference to the Answer of 14 March 2022 to Question 133232 on Antibiotics: Drug Resistance and to the policy paper entitled UK five-year action plan for antimicrobial resistance: 2019 to 2024, published on 24 January 2019, what recent progress her Department has made on halving healthcare-associated Gram-negative blood stream infections.

As described in the answer of 14 March 2022 to Question 133232, progress towards the target of halving healthcare-associated Gram-negative bloodstream infections (GNBSI) has proved very challenging, in part due to the diverse nature of the underlying causes of these infections. Data on the incidence of these infections in England is published quarterly by the UK Health Security Agency, and is available at the following link:

https://www.gov.uk/government/statistics/mrsa-mssa-gram-negative-bacteraemia-and-cdi-quarterly-report/quarterly-epidemiological-commentary-mandatory-gram-negative-bacteraemia-mrsa-mssa-and-c-difficile-infections-data-up-to-october-to-december-2023#epidemiological-analyses-of-gram-negative-bacteraemia-data

Incidence of the three main healthcare-associated GNBSI organisms, E. coli, klebsiella pneumoniae, and pseudomonas aeruginosa, has fluctuated between 2019 and 2024, including a sharp decline in the incidence of E. coli seen during the COVID-19 pandemic. However, overall, the total incidence of healthcare associated GNBSI remains significantly above the target.

We are currently developing the 2024 to 2029 antimicrobial resistance national action plan. We anticipate that in the delivery of this plan, we will continue to focus on GNBSI, building on lessons learnt over the past five years.