Global Health (Research and Development)

Heather Wheeler Excerpts

Tuesday 8th July 2014 Westminster Hall

[Heather Wheeler (South Derbyshire) (Con)]

I congratulate my hon. Friend the Member for St Ives (Andrew George) on securing this important debate on the future of global health, and specifically on the current position of research and development. I call Members’ attention to my trip to Ethiopia in the Register of Members’ Financial Interests. It is a pleasure to speak under your chairmanship, Mr Streeter.

I will focus my comments on the diagnostics aspects of research and development, which I was fortunate to witness and learn about at first hand during my time in Ethiopia. As part of our trip, we were taken around a hospital and shown an incredible set-up for diagnosing tuberculosis. The incidence of TB in Ethiopia is 274 cases in every 100,000 people, which ranks the country at approximately 20th in the world. That ranking is extremely good for a low-income country, thanks to its excellent diagnostic skills.

Diagnostics are often the forgotten third in the trilogy of drugs, vaccines and diagnostics. We need to change that thinking radically, as failure to diagnose diseases quickly is one of the key factors in the continuation of major epidemics. As Ethiopia has shown, excellent diagnostics can have a dramatic impact on reducing the incidence of infectious diseases. Shockingly, as many as half of those with HIV worldwide are undiagnosed, and one third of those with TB are not officially diagnosed or treated. We desperately need to rectify that, because the lack of diagnostics and of swift care and treatment can exacerbate endemics and heighten immunity to vaccination.

Specific diagnoses are extremely stilted, so it is imperative that doctors take the time to ascertain which strain of the disease the patient has. For example, TB can be drug resistant, but it can take months for tests to determine which drugs a strain of TB is resistant to. In the meantime, doctors often put patients on a standard regime of drugs, which can be disastrous, because some TB drugs unfortunately have severe and often permanent side effects, with several patients being left permanently deaf as a result.

DFID money has helped to develop GeneXpert, a machine that can diagnose TB in two hours and that can also diagnose certain strains of drug resistance. It is because of GeneXpert that patients are being diagnosed and starting treatment within hours, instead of weeks or months. GeneXpert machines have helped to oversee a transformation in some local health services. Owing to services’ increased capacity, health workers can collect samples, take them back to a central area for diagnosis, return to the patient and treat them at home. I actually saw that in the bush in Ethiopia. Such an approach reduces stress on the patient and on the health system, and it is much more efficient. Furthermore, battling TB worldwide has knock-on effects on TB in the UK. For example, the DFID-funded development of GeneXpert is now paying off, as the machine can now be used in UK hospitals.

Maximising the effectiveness of diagnostics requires intensive research in the field after a product has been developed, to ensure that the systems are in place to diagnose as many people as possible. In closing, I would like to ask the Minister whether DFID will commit, in future budgets, to supporting operational research programmes such as TB REACH to maximise the impact of new interventions.

[Several hon. Members]

rose—