Mitochondrial Transfer (Three-Parent Children)

Fiona Bruce Excerpts

Wednesday 12th March 2014 Westminster Hall

[Jacob Rees-Mogg]

I certainly think that this matter ought to come to the Floor of the House. I understand from an earlier debate that the Government are committed to full parliamentary scrutiny, but no doubt the Minister will confirm that.

To continue on PNT, at the one-cell stage the donor embryo pronuclei containing the nuclear genes are removed, killing that embryo. The partially gutted donor embryo with its healthy mitochondria is then used to form a new embryo when the pronuclei harvested from the commissioning woman’s embryo are inserted. Harvesting the pronuclei from the commissioning woman’s embryo kills that embryo.

It is important to understand that the techniques are non-therapeutic. They are in no sense a cure for children who are already born, nor do they pretend to be. Rather, the techniques create new people with altered genetic composition—genetically designed individuals who will not inherit mitochondrial disease. Although the mitochondrial DNA is around only 0.1% of a person’s total DNA, a little leaven leavens all the bread, and a different person is thereby created.

The proposed techniques all promote germ-line genetic modification. That is an infinite change that will lead to all the descendants of someone treated in this way being changed, the consequence of which cannot be known.

[Fiona Bruce (Congleton) (Con)]

I thank my hon. Friend for raising this critical subject. Techniques for mitochondrial transfer deliberately create a child who has three genetic ancestors, or, in the case of PNT, four. Is that not extremely concerning, raising as it does serious issues of personal identity for those born through the technique, particularly since Government guidelines propose that such individuals will not be allowed to know the identity of their third or forth parent? Will that not then transfer into future generations, too?

[Jacob Rees-Mogg]

I was going to come on to that. As an aside, the reason we were able to determine that Richard III’s body was his was through the female line, and because we could establish the continuity of the DNA. I do not believe Government promises of secrecy. They promised that to sperm donors historically. Governments cannot be relied upon, because society becomes more open and so demands greater openness. I have no doubt that if the technique is ultimately used the donors will be identified and people with three or potentially four parents will find out.