Genetic Technology (Precision Breeding) Bill (Third sitting)

Debate between Deidre Brock and Clive Lewis

Committee stage
Thursday 30th June 2022 Public Bill Committees

[Deidre Brock]

Q Which might be?

Professor Whitelaw: Craig might be able to answer this more clearly, but depending on the species, that might be breed books or production systems, which would be embedded within the companies or with different nations.

Dr Lewis: We should be very aware here that there is a species component to that. When we start thinking of cattle, for historical reasons, there is a very strong traceability element through the cattle chain. However, if we look at the pig industry in the UK, it is more done on a—shall we say—lot basis. For example, normal practice in the UK pig industry is to use pulled semen at a commercial level for a terminal sire, so even within a litter, you might have three or sires represented. That is today, so an individual animal traceability in the UK pig industry today does not really exist. When we answer the question on traceability and what exists today, that is very species-specific, rather than “This is the livestock sector.”

Professor Whitelaw: This is the basis of all of my thinking. We are using these tools to create precision changes to the genome—changes that can happen naturally. There is no difference between those two. There is a difference in how they arise; one is because we choose to target a specific DNA sequence and change it, and the other is just a random lottery that evolution throws up. However, from the animal’s perspective, and I would argue from our perspective, in how we look at these animals, it is just a genetic variation that exists. There is no difference. Going to the traceability question, why and what are you tracing?

[Clive Lewis (Norwich South) (Lab)]

Q I know you do not deal with IP, but if it is a natural occurrence, why is IP applicable? Surely, it is not invention; it is a genetic coding. I am just keen to know why you feel you then have the right to impose intellectual property rights on something that, as you are arguing to us, is naturally occurring. Yet, you will impose intellectual property, I would imagine, to be able to make a profit. I am finding a logical failing there. That is just to put that one out there, and maybe you can come back on to that.

We have been dealing with crops so far, and we have now moved on to animals. I must admit that I am now beginning to struggle with this slightly. We are not talking about plants but about sentient animals, and about genetic modifications to them.

The thing I have been reading about PRDC—porcine respiratory disease complex—is that part of it comes down to environmental and conditioning factors. There are obviously some pig farmers, for example, who keep their animals in better conditions than others, but many do not. Even when you keep your animals in optimal condition, there are certain conditions that they are kept in that will encourage that disease.

My question is on behalf of the millions of people who are increasingly becoming vegan or vegetarian. We are now introducing genetic editing to enable us to keep those animals in sometimes quite horrific conditions. It is for this disease at the moment, but what is to say that exploitation of these animals is not going to only deepen? Now we can keep these animals knee deep in their own crap—sorry, Ms McVey—and we can edit their genes so they can survive in those conditions. That is how some people will see this and that is how much of the public will see it. Can you give me some reassurance that that is not going to happen? When profit is the bottom line, I see these animals becoming more robust and able to live in ever-more extreme and difficult conditions.

Dr Rice: Perhaps I can jump in. If you have read about PRRS virus, you will probably know that it is actually not dependent on conditions. Animals in the wild, as well as animals in production, all get sick. What actually happens on farms today is that farmers have to install multimillion filtration systems—because viruses are airborne—to filtrate outside air through very complicated filtration systems so that viruses cannot get into the farm. So it actually has nothing to do with the conditions.

--- Later in debate ---

[Deidre Brock]

Thank you.

[Clive Lewis]

Q Mr Stevenson, if you could change the Bill, what are the key changes you would make? For example, do you agree ethically with the plant component of the Bill, in terms of gene editing plants, but not the animal side? You have talked about some of the changes that will need to be made on welfare and about putting the farmer, or whoever it is, in the driving seat with the changes you talked about just now. I am keen to know if you make a distinction between plant gene editing and animal gene editing. Does the Bill go far enough in the revisions that it makes to deal with gene editing of animals, or do you want to throw it out completely?

Dr Mills, on gene edited exports, one presumes that once this biotechnology is achieved, it does not make a difference what welfare rights we have in this country for animals. A big part of the Bill is giving British biotechnology the ability to get out in front on this, and we could then sell that technology to other countries that have much lower animal welfare standards. Is that a concern?

Peter Stevenson: I do not know enough about plants to give a proper opinion. When it comes to the animal side, as I said earlier, there are a few cases in which I think gene editing could be beneficial, but ideally I would like to see animals removed from the Bill and much more thought given to how gene editing is going to be used and what protections should be there before legislation is introduced.

For example, the arguments that gene editing can be beneficial in terms of disease resistance have been overstated. Yes of course, if you are looking at diseases that have nothing to do with the way animals are being kept, gene editing for disease resistance can be helpful, but the science is absolutely clear that many diseases stem from keeping animals in intensive conditions. Very specifically, the crowded, stressful conditions in intensive livestock production can lead to the emergence, the spread and the amplification of pathogens. Gene editing should not be used to tackle such diseases. These diseases should be addressed by keeping animals in better conditions. There is a very real danger that if you gene edit for resistance to diseases that primarily result from keeping animals in poor conditions, that could lead to animals being kept in even more crowded, stressful conditions, because they may be resistant to the diseases that are inherent in such conditions.

Having said all that, I suspect Government isn’t about to drop animals from the Bill. I have talked about how the Bill should be strengthened in terms of giving a stronger central role to the welfare advisory body, but it also needs to be strengthened in setting out what that body should be looking at. The Bill is very unusual. Usually primary legislation provides more definition.

For example, the welfare advisory body should be looking for things like a piece of gene editing aimed at animals growing faster or providing higher yields, and asking, “Has this caused a problem for animals that have been selectively bred for such purposes?” If it has, it should be very careful and look at whether that is likely to happen with gene edited animals. It should also be asked to look at whether the desired objective of the gene editing could have been achieved in less intrusive ways. An awful lot more thought needs to be given to the use of gene editing in animals.

I will add one point. It is more than 50 years since Ruth Harrison’s book “Animal Machines” first alerted us to the dangers of intensive livestock farming, yet gene editing is doing exactly that: treating animals as machines that can be fine-tuned to make them a bit more convenient for us. The Bill sits at considerable odds with the recent Animal Welfare (Sentience) Act 2022 that regards animals as sentient beings. The two do not mesh.

Dr Mills: To pick up on what Mr Stevenson said and to clarify, the Nuffield Council certainly sees many benefits in genome editing as applied to animals. Unlike perhaps a number of other commentators on the issue, we does not see genome editing as necessarily being the last resort. We recognise that, in some cases, there are social conditions that are every bit as intractable as the biology of animals; indeed, given the technologies that are becoming available to us, the biology of animals is perhaps more tractable. Our way of approaching this is to treat those things symmetrically and to consider in what way different interventions might promote a just, healthy and sustainable food and farming system, taking into account the interests of the people and animals that are dependent on that system.

You asked about the technology being sold to countries that have lower animal welfare standards than the UK. I am very happy to live in the UK, a country that does respect animal welfare. Of course, the science and the technology are very easily translated across national and jurisdictional boundaries, but that really is an argument for the governance of breeding according to purposes. It should be consistent with the purpose of securing safe, just and sustainable food and farming systems. A technology can be applied in any number of contexts, and one cannot necessarily control them all. However, if you set out in the right direction, you have a much better chance of arriving at a desirable destination.

Dr Campbell: Chair, may I comment on that?

Genetic Technology (Precision Breeding) Bill (Second sitting)

Debate between Deidre Brock and Clive Lewis

Committee stage
Tuesday 28th June 2022 Public Bill Committees

[Deidre Brock]

That is really helpful, thank you.

[Clive Lewis]

Q I am just trying to get my head around some of the comments that have been made so that I can apply them to the legislation. I think Mr Angus felt that intellectual property rights were a potential barrier to entry, whereas you felt that an excessive regulatory framework was a barrier to entry. What would the main barrier be?

Professor Napier: In my opinion, it is regulatory approval that is the barrier.

--- Later in debate ---

[Deidre Brock]

Although it is certainly bound up in the arguments about gene editing and genetic modification.

Dr Harrison: In many ways, among the small and medium-sized enterprises such as Bill’s, in a landscape such as the UK, where there is a lot of innovation happening, there are start-ups starting now that want to do breeding and gene editing, so you may well see the opposite happening: a democratisation of the process and more people entering the market as the barrier to entry is much lower because of the regulation change.

Professor Oldroyd: The food production sector is no different from any other sector in this free market economy. I hear a lot of concerns about a few companies owning most of the seeds, but I do not hear the same about a few companies owning most of the drugs, cars, phones, clothes or any other product. That is a reality of our free market economy. The food production system is just like any other sector; there are major players who have a sizeable part of the market share.

Richard made a very important point. The phenomenal restrictions that are being put on traditional genetic modification have actually meant that only the big players that have deep pockets can use that technology. I feel as though we have ended up in the situation that most people feared, where a few companies have total control of a technology, and that is principally because of the cost of releasing those traits. If we follow the Bill and treat them as equivalent to conventional breeding, we absolutely liberate the technology for SMEs to get in the game. At the moment, they could not afford to do that with GM.

[Clive Lewis (Norwich South) (Lab)]

Q It is good to see you again, Professor Oldroyd and Dr Harrison. Your last comments have thrown my question in many ways. You said that not much is said about pharmaceuticals and other products in the free market, but that is quite a low bar. I have been involved with the trade-related aspects of intellectual property waiver campaign. A big part of the global south is campaigning to have access to the understanding of how to make anti-covid drugs, and they are struggling.

I do not think that is a model that I would want to apply to food. Some of us would like to see something more robust that did not make the mistakes that we have made on pharmaceuticals, for example. Food supply is critical, especially as we move through the 21st century with the climate crisis and a growing population. When I was asking you questions as a BBC journalist a long time ago, I was always struck by your passion for the science and for communicating the science. As currently constructed, does the Bill provide the protections we need? Outside your laboratories, away from the pure science, there are free-market corporations for which the bottom line is the end game and the main driver. Do you feel that this science is beyond abuse and beyond being used in the same way that perhaps big pharma have cornered those markets?

Lastly, I understand the notion that reducing barriers opens up the market to small and medium-sized companies, but the history of any industry shows us that big players begin to hoover up small players over decades, and you end up back in an oligopoly or monopoly situation. That does not necessarily have to happen, but that is what usually happens with new tech. There is a free-for-all when everyone piles in, but ultimately people sell up and move on, and the big companies hoover up. When you get past the science and it reaches the real world, do you feel that there is the opportunity for abuse? Does the Bill protect us from that?

Professor Oldroyd: With the caveat of clause 3, legislating gene editing as equivalent to conventional breeding is the best way to allow small to medium-sized enterprises to become involved in the technology. If you really want to see a break in major corporate ownership, lowering the barriers to how you get a product from that technology is almost certainly going to facilitate that. As I said earlier, the big problem currently with GM is that it is so costly to release a GM variety that only “the big four” can afford to do that. I think that taking this approach will help that ownership of lines.

Certainly from me, as a researcher, the Bill as it currently stands greatly facilitates me to work directly with plant breeders and move products through the conventional plant breeding mechanism into the market and on to the consumer. Some of that plant breeding is in the big four, but quite a bit of it is not. Those are more the medium-sized enterprises, not necessarily BASF or Bayer, although they do have a role in some of that. I think the current Bill will certainly facilitate that broadening of ownership of the technology and a speeding up of the impact to the consumer.

Dr Harrison: If I could add one small point, our public research institutes in the UK have a pivotal role to play here. We do research funded by the Government in this area and we publish that. We can protect it before or we can just publish it so it is free and able to be used by many.

You could really think strategically about how those research organisations are used to direct change in the way that one would want to see, so that varieties come on to the market either nearly complete, so breeders can take them up, which is often what happens, or even release complete varieties, as happens in many other countries, from public funded research organisations. Again, that allows freedom of choice, so varieties come on to the market that have traits that are desirable and do not suffer from the problem you point out, which is that some small companies may become subsumed into larger companies.

Thinking about it more broadly—this is outside the scope of the Bill—there is an absolute opportunity for the UK to lead on bringing those traits to the point at which they can be taken to market, in a variety of different ways that are not just dependent on the big four.

Genetic Technology (Precision Breeding) Bill (Second sitting)

Debate between Deidre Brock and Clive Lewis

Tuesday 28th June 2022 Public Bill Committees

[Deidre Brock]

That is really helpful, thank you.

[Clive Lewis]

Q I am just trying to get my head around some of the comments that have been made so that I can apply them to the legislation. I think Mr Angus felt that intellectual property rights were a potential barrier to entry, whereas you felt that an excessive regulatory framework was a barrier to entry. What would the main barrier be?

Professor Napier: In my opinion, it is regulatory approval that is the barrier.

--- Later in debate ---

[Deidre Brock]

Although it is certainly bound up in the arguments about gene editing and genetic modification.

Dr Harrison: In many ways, among the small and medium-sized enterprises such as Bill’s, in a landscape such as the UK, where there is a lot of innovation happening, there are start-ups starting now that want to do breeding and gene editing, so you may well see the opposite happening: a democratisation of the process and more people entering the market as the barrier to entry is much lower because of the regulation change.

Professor Oldroyd: The food production sector is no different from any other sector in this free market economy. I hear a lot of concerns about a few companies owning most of the seeds, but I do not hear the same about a few companies owning most of the drugs, cars, phones, clothes or any other product. That is a reality of our free market economy. The food production system is just like any other sector; there are major players who have a sizeable part of the market share.

Richard made a very important point. The phenomenal restrictions that are being put on traditional genetic modification have actually meant that only the big players that have deep pockets can use that technology. I feel as though we have ended up in the situation that most people feared, where a few companies have total control of a technology, and that is principally because of the cost of releasing those traits. If we follow the Bill and treat them as equivalent to conventional breeding, we absolutely liberate the technology for SMEs to get in the game. At the moment, they could not afford to do that with GM.

[Clive Lewis (Norwich South) (Lab)]

Q It is good to see you again, Professor Oldroyd and Dr Harrison. Your last comments have thrown my question in many ways. You said that not much is said about pharmaceuticals and other products in the free market, but that is quite a low bar. I have been involved with the trade-related aspects of intellectual property waiver campaign. A big part of the global south is campaigning to have access to the understanding of how to make anti-covid drugs, and they are struggling.

I do not think that is a model that I would want to apply to food. Some of us would like to see something more robust that did not make the mistakes that we have made on pharmaceuticals, for example. Food supply is critical, especially as we move through the 21st century with the climate crisis and a growing population. When I was asking you questions as a BBC journalist a long time ago, I was always struck by your passion for the science and for communicating the science. As currently constructed, does the Bill provide the protections we need? Outside your laboratories, away from the pure science, there are free-market corporations for which the bottom line is the end game and the main driver. Do you feel that this science is beyond abuse and beyond being used in the same way that perhaps big pharma have cornered those markets?

Lastly, I understand the notion that reducing barriers opens up the market to small and medium-sized companies, but the history of any industry shows us that big players begin to hoover up small players over decades, and you end up back in an oligopoly or monopoly situation. That does not necessarily have to happen, but that is what usually happens with new tech. There is a free-for-all when everyone piles in, but ultimately people sell up and move on, and the big companies hoover up. When you get past the science and it reaches the real world, do you feel that there is the opportunity for abuse? Does the Bill protect us from that?

Professor Oldroyd: With the caveat of clause 3, legislating gene editing as equivalent to conventional breeding is the best way to allow small to medium-sized enterprises to become involved in the technology. If you really want to see a break in major corporate ownership, lowering the barriers to how you get a product from that technology is almost certainly going to facilitate that. As I said earlier, the big problem currently with GM is that it is so costly to release a GM variety that only “the big four” can afford to do that. I think that taking this approach will help that ownership of lines.

Certainly from me, as a researcher, the Bill as it currently stands greatly facilitates me to work directly with plant breeders and move products through the conventional plant breeding mechanism into the market and on to the consumer. Some of that plant breeding is in the big four, but quite a bit of it is not. Those are more the medium-sized enterprises, not necessarily BASF or Bayer, although they do have a role in some of that. I think the current Bill will certainly facilitate that broadening of ownership of the technology and a speeding up of the impact to the consumer.

Dr Harrison: If I could add one small point, our public research institutes in the UK have a pivotal role to play here. We do research funded by the Government in this area and we publish that. We can protect it before or we can just publish it so it is free and able to be used by many.

You could really think strategically about how those research organisations are used to direct change in the way that one would want to see, so that varieties come on to the market either nearly complete, so breeders can take them up, which is often what happens, or even release complete varieties, as happens in many other countries, from public funded research organisations. Again, that allows freedom of choice, so varieties come on to the market that have traits that are desirable and do not suffer from the problem you point out, which is that some small companies may become subsumed into larger companies.

Thinking about it more broadly—this is outside the scope of the Bill—there is an absolute opportunity for the UK to lead on bringing those traits to the point at which they can be taken to market, in a variety of different ways that are not just dependent on the big four.