Animal Experiments

(asked on 15th October 2021) - View Source

Question to the Department for Business, Energy and Industrial Strategy:

To ask the Secretary of State for Business, Energy and Industrial Strategy, with reference to the Centre for Economics and Business Research report, The economic impact of the UK’s New Approach Methodologies sector, on behalf of Animal Free Research UK, published 6 October 2021, what steps he is taking to provide support for the NAMs industry and accelerate the replacement of animals in research in addition to providing funding for the National Centre for the Replacement, Refinement and Reduction of Animals in Research.


Answered by
George Freeman Portrait
George Freeman
This question was answered on 20th October 2021

The Government actively supports and funds the development and dissemination of techniques that replace, reduce and refine the use of animals in research (the 3Rs). This is achieved primarily through funding for the National Centre for the 3Rs (NC3Rs), which works nationally and internationally to drive the uptake of 3Rs technologies and ensure that advances in the 3Rs are reflected in policy, practice and regulations on animal research.

The NC3Rs receives its core funding from UK Research and Innovation (UKRI)’s Medical Research Council (MRC), and Biotechnology and Biological Sciences Research Council (BBSRC). Since the NC3Rs was launched in 2004, it has committed £100 million in research to develop 3Rs technologies.

In 2015, the NC3Rs with Innovate UK, alongside the MRC, BBSRC, Economic and Social Research Council, and the Defence Science and Technology Laboratory, developed the non-animal technologies roadmap setting out a 2030 vision and strategy for how non-animal technologies could be used to replace the use of animals in research across a number of sectors for the UK.

The roadmap sets a vision and strategy to accelerate the translation of technologies emerging from research into tests for assessing the safety and efficacy of chemicals (including medicines and drugs) without the use of animals and to guide those working in this area to adopt more humane approaches.

In addition to funding the NC3Rs, UKRI also funds a portfolio of research projects involving humans, human materials, animal models, and non-animal technologies. The replacement, refinement and reduction principles are embedded in all the research within UKRI’s remit involving (or potentially involving) animal use. UKRI also encourages grant applicants, including those whose research does not involve animals but could contribute to greater reduction and replacement, to consider further opportunities to advance the 3Rs.

The MRC has recently launched a new Precision Medicine Accelerator to take the most exciting ideas from discovery science into research using humans, focused on early clinical application. The first step was the establishment of the Experimental Medicine Panel in 2020, which has so far awarded £5.5 million to projects investigating the mechanisms behind diseases such as liver failure, polycystic ovary syndrome, vasculitis, mild autonomous cortisol secretion and malaria.

Between 2015-2019, the BBSRC spent over £7 million on research grants aimed at developing and applying innovative methodologies to studying human and animal physiology, including in silico approaches, organ-on-a-chip, organoid and other advanced cell culture systems.

Reticulating Splines